Hypotension Due to Kir6.1 Gain‐of‐Function in Vascular Smooth Muscle
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چکیده
منابع مشابه
Hypotension Due to Kir6.1 Gain‐of‐Function in Vascular Smooth Muscle
BACKGROUND KATP channels, assembled from pore-forming (Kir6.1 or Kir6.2) and regulatory (SUR1 or SUR2) subunits, link metabolism to excitability. Loss of Kir6.2 results in hypoglycemia and hyperinsulinemia, whereas loss of Kir6.1 causes Prinzmetal angina-like symptoms in mice. Conversely, overactivity of Kir6.2 induces neonatal diabetes in mice and humans, but consequences of Kir6.1 overactivit...
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ژورنال
عنوان ژورنال: Journal of the American Heart Association
سال: 2013
ISSN: 2047-9980,2047-9980
DOI: 10.1161/jaha.113.000365